Friday, June 2, 2023

Chemo is Weird, Y'all

Been watching this YouTuber, Hank Green, for about 13 years.  (The first video I saw is this one:  https://www.youtube.com/watch?v=yRRGaxx8Zf4)

A couple of weeks ago he announced that he had lymphoma:  https://www.youtube.com/watch?v=x6a4hMyiwBo

https://www.youtube.com/watch?v=hpRTrdMZGLQ

He alternates making youtube videos with his brother John, who wrote the book, "The Fault in Our Stars" which was made into a terrific movie.  John Green appears in a deleted scene of the movie:  https://www.youtube.com/watch?v=PEEQ6-4nKYQ

Saturday, May 27, 2023

"I looked at the recent bird flu data, and now I'm really scared."

An elderly friend of mine in Salt Lake City died from the flu.

According to the video, there is no pandemic of the Bird Flu right now, but conditions are ripe for one to happen.  It has infected animals close enough to humans for it to have the potential to spread to people.

The video claims that public officials are trying to prevent an outbreak.  It would be good if we could avoid another pandemic.

https://www.youtube.com/watch?v=ALduFqONN58

Friday, May 26, 2023

Does COVID Mess With Your DNA?

https://youtu.be/6q_Sf4I0Bp0

What I gather from the video is that the methylation of genes is a natural bodily response to infection. People with long COVID appear to have overly persistent and/or inappropriate methylation leading to chronic inflammation.

Friday, May 19, 2023

You drink this insecticide every day. #shorts #science #SciShow

https://youtube.com/shorts/XVQDG3ygXvE?feature=share

What's in your fast food chicken sandwich? Seaweed, wood and more

Your Brain Is Shaped Like Nobody Else’s - Nautilus

growing body of research now confirms there are plenty of physical dissimilarities between individual brains, particularly when it comes to white matter—the material nestled beneath the much-prized gray matter. And it's not just anatomical. White matter hosts connections between the brain's sections, like a city's streets and avenues. So behavioral patterns can arise from even small physical differences in white matter, according to a late 2022 Science paperpenned by Forkel and a colleague.1

https://nautil.us/your-brain-is-shaped-like-nobody-elses-297950/


Thursday, May 4, 2023

"76% of the people in Hong Kong who died of COVID were vaccinated"

There are problems with this idea.  People in Hong Kong don't get the same vaccine as Americans.  Most get the ineffective Chinese vaccine.  You would have to compare the death rates with other people in the world.   

The overall mortality rate in the United States among the unvaccinated has varied from 2 to 10 times as much.


"In January, only about 25% of Hong Kong residents aged 80 and older had been jabbed, with the rate among care home residents even lower. Almost all of those who perished in the fifth wave, about 72%, were unvaccinated."

How the ‘Unvaccinated’ Got It Right

https://www.theepochtimes.com/health/how-the-unvaccinated-got-it-right_5238208.html?utm_campaign=socialshare_email

I am disturbed by how every commentator on the political right has turned anti-COVID-vaccine to one degree or enough.  While most are against the vaccine, some think it should only be given to the most vulnerable population because of reported vaccine risk.

The article cherry-picks its data and makes a number of false claims.  It hits every anti-vaccine point that has come up over the last three years and relies on emotional language to make its points.

1. It is not true that the vaccinated die at a higher rate than the unvaccinated.  The data shows so much the opposite that it takes extreme mental gymnastics to come to this conclusion.

The article points to data from the vaccine trial.  The problem with this is that the vaccine trial was given to a wide range of people, including nursing home patients who might have died anyway, so any discussion of the death rate from the initial trial is not proof of anything.  https://www.oregonlive.com/coronavirus/2021/08/no-more-vaccinated-people-didnt-die-from-covid-in-pfizers-vaccine-trial.html

There has been a ton of research after the initial trial.  I have read a number of papers that support the safety and efficacy of the vaccines.

I saw one study that indicated that 1 out of a million people might die from the vaccine, usually people with comorbidities.  This is roughly the same risk of death every time you get in a car.  However, the disease has killed 1 out of 92 infected people in the United States, usually people with comorbidities.  Young healthy people have also died from COVID.   Nobody claims that the vaccine is perfectly safe, or effective, but the relative risk is much lower.  One out of every 285 Americans has died from COVID.  I lost a cousin to COVID.

The efficacy of the vaccine has changed as the disease has evolved.  Because of this, many people claim that the government lied to us about the efficacy of the vaccine.  Although the vaccine is now less effective at preventing the disease, the data shows that it is still 97% effective at preventing hospitalization and death.

2.  It is not true that the vaccine is untested.

3.  The vaccine was not tested for stopping the spread of the virus.  

Although initially true, there wasn't time before the Emergency Use Authorization to determine whether the vaccine stopped the spread of the virus.  Most commentators take this to mean that it doesn't.  However, I have read more recent scientific studies that show that vaccinated people are much less likely to spread the disease.

If a member of your family has COVID, wouldn't you prefer that they be vaccinated?  According to at least one study, the vaccinated are less likely to spread the disease to a family member.

4.  The article claims that the vaccine mRNA might not be eliminated inside the body, without offering any proof, further making the unsupported claim that this could harm our health.

It is a well-known medical fact that mRNA is destroyed in less than a second after it is used.  Your body is making and disposing of mRNA every microsecond.

Even if some of the vaccine mRNA stays around, there is no vehicle for the mRNA to enter other cells.  The vaccine needs a lipid delivery mechanism to work.  Once the mRNA enters the cell, it loses this mechanism.

5.  The article claims that there are no long-term vaccine risk studies.

This is most likely true, although it depends upon what you mean by long-term.  There have been more studies on the COVID disease and vaccination than any other disease.

"no long-term side effects have been detected. "
https://portal.ct.gov/vaccine-portal/Vaccine-Knowledge-Base/Articles/Long-Term-Effects?language=en_US

However, the long-term effects of the COVID disease have been severe, with about 11% of the infected getting "long covid".  This can be life-threatening or completely debilitating.
https://www.youtube.com/watch?v=dpjGLLbWZJ0

6.  The article claims that the government violated people's civil liberties and engaged in censorship, and this is a good reason to not get vaccinated.

The first part of this statement is true, but it would be like saying that because you live in communist China you should not get vaccinated.  The efficacy and safety of the vaccine is a completely different issue from the oppressive nature of governments.

Wednesday, April 12, 2023

What’s next for COVID-19 vaccines? Scientists and regulators chart a course amid uncertainty | Science | AAAS

A case of fatal multi-organ inflammation following COVID-19 vaccination - PMC

"1. Introduction
Coronavirus disease 2019 (COVID-19) vaccines are available worldwide. Since their introduction, post-vaccination deaths have been reported, and their association with the vaccine has been forensically examined [1], [2]. Post-vaccination myocarditis and pericarditis have been increasingly reported, with male adolescents reported to have a higher incidence of pericarditis with a good prognosis, while middle-aged and older patients are more likely to have severe myocarditis. In this study, we report an autopsy case of a 14-year-old girl who died unexpectedly 2 days after receiving the third dose of BNT1262b2 mRNA COVID-19 vaccine.

2.4. Diagnosis

A diagnosis of vaccine-related multiple-organ inflammation was made based on the absence of bacterial or viral infection, lack of a past medical history suggestive of autoimmune disease, no allergic reaction, and no drug exposure other than the vaccine. Myopericarditis is a form of multiple-organ inflammation. Although pneumonia is involved, pneumonia alone is rarely a cause of sudden death, and the presence of erythrocyte-laden macrophages as well as congestive edema of the lungs on histology suggested signs of heart failure


3.1. Death after COVID-19 vaccination:

Vaccine development and its widespread application are key elements in the fight against the COVID-19 pandemic. The COVID-19 vaccine is now used worldwide and has contributed to the containment of the pandemic. However, adverse events caused by vaccines have been a problem. A forensic examination for the evaluation of the association between vaccination and death was conducted in cases of post-vaccination deaths [1], [2], [4]. The majority of these cases were negatively associated with vaccination; however, anaphylaxis, vaccine-induced immunothrombotic thrombocytopenia, myocarditis, and pericarditis have all been listed as having a suspected association with vaccination and vaccination-related death [2], [4]. Murata et al. also reported four cases of death after vaccination, in which the only autopsy findings were organ congestion with no evidence of myocarditis. RNA analysis of the blood showed that neutrophil degranulation and cytokine signaling were upregulated in the control group, which led them to conclude that the deaths were due to cytokine storm


3.2. Myocarditis and pericarditis after COVID-19 vaccination

Reports of myocarditis and pericarditis after COVID-19 vaccination have increased since the report by Albert et al. [6]. The frequency of occurrence of myocarditis and pericarditis has been reported in a US military survey including 23 cases of myocarditis/2,800,000 persons with a mean age of 25 years, all males, and no deaths [7]. A total of 40 U.S. hospitals reported 20 cases/2,000,287 with myocarditis and 37 cases/2,000,287 with pericarditis; both groups showed male predilection, mean age of onset of 36 years for myocarditis and 59 years for pericarditis, and no deaths in either group [8]. The Nordic cohort study reported that myocarditis occurred in 1,077/23,122,522 patients and pericarditis in 1,149/23,122,522 patients; both were more common in young men aged 16–24 years and most commonly occurred after the second vaccination [9]. Thus, post-vaccination myocarditis and pericarditis had incidence rates of 0.0008–0.0047% and 0.0019–0.0050%, respectively. Although usually mild, these conditions can occur; however, severe cases resulting in death are rare. As of September 2022, the number of COVID-19 vaccine recipients in Japan was approximately 103 million for the second dose and 82 million for the third dose [10]. Based on the above report, at least 800 cases of myocarditis and approximately 1,500 cases of pericarditis occurred after vaccination in Japan. Since the incidence of myocarditis and pericarditis is reported to be higher with second dose of the vaccine than with first dose [11], third dose of the vaccine are likely to further increase the frequency of occurrence of the disease.

The mechanism by which the COVID-19 vaccine causes myocarditis and pericarditis is unclear; however, several hypotheses have been proposed. The mRNA vaccine results in modifications to the nucleoside to reduce its antigenicity. In some individuals, mRNA is recognized as an antigen, resulting in the activation of the inflammatory cascades and immune pathways; in such cases, myocarditis occurs as part of a systemic inflammatory response"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027302/

The numbers show a fairly low risk of side effects from the vaccine, with death being rare.  The vaccine is not without risk, but based on what I have read, the disease is about a thousand times more likely to cause the same problems.   In the risk versus benefit analysis, you are better off with the vaccine.  

However, the pandemic is almost over.  I don't know what will happen if people stop getting vaccinated, but given the small risk from vaccination, many people may choose not to get it.



Saturday, March 25, 2023

Irrational humans

I would have thought that a deadly pandemic would have united the human race to a common cause to defeat an enemy killing so many people.  However, instead of the pandemic joining us, it divided us even further.  

The evidence shows that the vaccine reduces your overall chances of dying by a considerable amount.  Nevertheless, I daily see attacks on the vaccine as if it were some sort of plague.   People have a right to make poor choices, but the amount of misinformation is vast, which affects people's ability to make decisions.

If COVID had a smallpox death rate then I don't think there would be any argument.  Everybody would be lining up for the vaccine, regardless of any potential side effects.  However, a death rate of 1% (or less) is still pretty significant if you or a loved one is the one who dies.

This has caused me to reflect on why humans are so irrational.  I am seeing what I think is a common factor in how people make decisions.  This ties into politics.  I have long noticed people are much more intense about the things that they are opposed to.  I am calling this the "boogeyman factor."   The thinking is that those people over there are going to do something that we don't like so we are going to fight them no matter what.  People naturally focus more on adverse outcomes because fear is the most powerful motivator.  On the other hand, if you are a happy person who has few worries, which is almost no one, then you might not have much need for politics.

In our current era, we have become very tribal, with no middle ground or nuance.   Ask anyone, regardless of party, about politics and they will name at least one evil person that needs to be defeated.  It is human nature to need an enemy that we can fight, and in recent years we will vilify just about anyone.

When it comes to the vaccine there are quite a few "boogeymen", whether that be Donald Trump, Joe Biden, Anthony Fauci, Bill Gates, "big pharma", or the government.  There are a great many people who are thoroughly convinced that evil forces are trying to hurt us, by one means or another, so they are unwilling even to consider the vaccine because it comes from an evil source.

Once people make up their minds, confirmation bias becomes very strong.  They will look only at evidence that supports their position while ignoring evidence to the contrary.

--
Best wishes,

John Coffey

Tuesday, March 7, 2023

COVID Numbers are down

The COVID numbers were somewhat steady for months, but have turned downward.  We have gone from about 500 deaths per day, which seemed significant to me, to only about a hundred.

I was at the Columbus, Indiana hospital yesterday when they dropped their mask mandate.

Does this mean the Pandemic is over?  Not for some people, but the rate of the disease doesn't seem very threatening right now.

This is not what I thought would happen.  COVID is very good at both spreading and mutating, and given the number of people who aren't fully vaccinated, I thought that we would be dealing with this for many years.

I used to watch "Physics Girl" on Youtube.  Her Long COVID has become so severe that it has become life-threatening.  This is from an infection that she had eight months ago.









The origin of COVID: Did people or nature open Pandora’s box at Wuhan? - Bulletin of the Atomic Scientists

Friday, February 24, 2023

Vaccines prevent COVID-19 spread

 A sore spot for me is the claim made by every single conservative talk show host that the vaccines do not stop the spread of COVID-19 and that we were lied to when the government said that they would.  This claim is based on testimony by Janine Small to the European Union who said that they did not have time in their initial testing to determine if the vaccines stop the spread of the disease.  However, those studies have since been done.   I have found studies showing that the vaccines reduce the spread of COVID-19.  It also makes sense that if you reduce infection then you also reduce spread.  This logic is almost irrefutable, so it would be perfectly proper for the government to make this claim.

United States: COVID-19 weekly death rate by vaccination status, All ages

 https://ourworldindata.org/grapher/united-states-rates-of-covid-19-deaths-by-vaccination-status?country=~All+ages

Thursday, February 23, 2023

Dianna Cowern Physics Girl

This is popular Youtuber, Physics Girl, Dianna Cowern

https://www.youtube.com/shorts/sOhdQNjmK_U

Reportedly, she has been suffering from "Long COVID" since July.  She has made this public.



Things got worse and she went to the ER last week.


She is clearly suffering because of this.  I have long believed that COVID is something that we should take seriously.  It is not an ordinary disease.  It is not just the cold or a bad flu.

I looked to see if there is an update on her condition.  Nothing yet.



Thursday, February 16, 2023

Brain injury after vaccination

https://www.youtube.com/watch?v=NZhzWzoPB3M


John Coffey  0 seconds ago:

It is not clear to me that the vaccine causes an excess number of these cases. There is an assumed causality that is not proven.

The U.S. Government statistics show a much lower overall death rate among the vaccinated.

The quoted study concludes with ...  

"Neurological manifestations following the SARS-CoV-2 vaccination have been reported, and although they are few in number, healthcare professionals should be alert to their presentation as a high vigilance and rapid response to these events are the need of the hour. Further investigations are required to establish a definitive causal association with the currently recommended vaccines. Until then, the benefit of protection against COVID-19 for both individuals and society is far greater than the hypothesized risk of these adverse events."

Friday, February 10, 2023

Yes, masks reduce the risk of spreading COVID, despite a review saying they don't

An updated Cochrane Review published last week is the latest to suggest face masks don't work in the community.

However there are problems with the review's methodology and its underpinning assumptions about transmission.

An RCT comparing occasional versus continuous use of respirators in health care workers showed N95 respirators and surgical masks were equally ineffective when only worn occasionally by hospital workers. They had to wear them all the time at work to be protected.

We also combined only apples and apples in a meta-analysis of two RCTs conducted in exactly the same way and measuring the same interventions and outcomes. We found N95 respirators provide significant protection against respiratory infections when surgical masks did not, even against infections assumed to be "droplet spread".

https://theconversation.com/yes-masks-reduce-the-risk-of-spreading-covid-despite-a-review-saying-they-dont-198992

Saturday, February 4, 2023

Dopamine: More Than Pleasure, The Secret is the Anticipation of a Reward - LiveInnovation.org

"The reason for it is because the uncertainty of receiving the reward creates a much greater expectation and therefore dopamine production."

Speaking on a personal level, I seem to get addicted to some things easily.  

When I was in college 40 years ago, I noticed something about playing table tennis.  After I hit the ball I had a high level of anticipation about what was going to happen next, which was only a couple of seconds away, but unknown until it actually happened.  I realized then that this high level of anticipation made the game addicting.  Pinball seems to work the same way.  

Maybe one reason why there is still a cult following for the 42-year-old video game Donkey Kong, which I still like to play, is that it has a great deal of randomness built into the game.  There is no set predictable pattern that you can follow.  Parts of the game are predictable, but frequently you have to react within a couple of seconds to an ever-changing circumstance.  The game can be an intense experience.

I think that there could be a similar appeal to gambling because the gambler is anticipating an unknown outcome.

On the surface, this would seem unrelated to watching a ton of youtube videos, which has been a problem for me lately.  Youtube has a bunch of interesting content, but even before you finish one video, they are recommending other content that you might like.  I have a natural tendency to be curious about everything, so I want to see what this other content has to offer.  There is anticipation there.  It is like they know how to keep me hooked.

TikTok has admitted that they use an algorithm to keep people addicted.  The way it works is that they show you a list of videos with the best videos interspersed along the list  The idea is to keep you scrolling looking for the best videos.  Maybe TikTok is evil.

Social media creates anticipation of positive feedback from other people.

Perhaps if a person is aware of how they are being manipulated on a psychological/neurotransmitter level, then maybe they can change their behavior by not falling for this trap.

A Floridian's Guide to Living Someplace Very Very Cold

Friday, February 3, 2023

COVID vaccines slash risk of spreading Omicron — and so does previous infection

https://www.youtube.com/watch?v=JgrMzvasrm8&t=1100s

"Decreases in transmission of the delta variant were greater after two BNT162b2 vaccinations"

"The team found that among individuals with COVID-19, those who received at least one vaccine shot were 24% less likely to infect close contacts"


"This study confirms that COVID-19 vaccination reduces the risk of delta variant infection and also accelerates viral clearance in the context of the delta variant. However, this study unfortunately also highlights that the vaccine effect on reducing transmission is minimal in the context of delta variant circulation. These findings have immediate public health implications. Higher vaccination coverage rates need to be achieved because indirect protection from vaccinated to unvaccinated people remains suboptimal."

"Pfizer vax did reduce transmission of early variants"

"Researchers in the United Kingdom reported in a February observational study that Pfizer's vaccine helped cut transmission of the alpha and delta variants."


"Scientific studies show that the Pfizer-BioNTech COVID-19 vaccine reduces transmission"

"However, when booster vaccine doses reduce the risk of infection (as shown in the study by Spitzer et al2), then these boosters will also prevent transmission. As with all infectious diseases, the pathogen is required to cause the disease, and SARS-CoV-2 infection is the sine qua non for COVID-19. Prevention of infection results in prevention of potential onward transmission from all individuals who are spared the infection."

"New research suggests COVID-19 vaccines can slow the spread of disease, even with Omicron"

"Early data suggest infections in fully vaccinated persons are more commonly observed with the Delta variant than with other SARS-CoV-2 variants. However, data show fully vaccinated persons are less likely than unvaccinated persons to acquire SARS-CoV-2, and infections with the Delta variant in fully vaccinated persons are associated with less severe clinical outcomes. Infections with the Delta variant in vaccinated persons potentially have reduced transmissibility than infections in unvaccinated persons, although additional studies are needed."

"Instead, it's the principle that the UKHSA identified above: if you don't get infected in the first place thanks to a vaccine, you can't spread it. Once you're infected, you still can"

How Alcohol Harms Your Body

Wednesday, February 1, 2023

Significant Events

Until recently, the most significant thing to happen in my lifetime was 9-11.   It had a profound effect on this country and its foreign policy, and it also had a profound effect on me because I went to work for a defense contractor.  It also temporarily brought Americans together to fight a common enemy.

In terms of the number of people affected, 9-11 is small potatoes compared to the COVID-19 pandemic.  There have been 675 million cases worldwide, with 6.76 million deaths.  In the United States, there have been 104 million cases with 1.1 million deaths.  Roughly 1 out of every 300 Americans has been killed by COVID-19.  However, when it comes to fighting the disease, this common enemy did not bring us together but made us more divided.

Perhaps the most important thing in the world right now is that we don't get into a nuclear war with Russia or China or any other potential adversary.  Since this is not likely to happen, I'm not too worried about it.

So the second most important thing in the world is how we handle the COVID-19 pandemic both personally and in terms of public policy.  The actions we take could save or cost lives.  

Most people today see the pandemic in the rearview mirror.  The public seems very lax.  People stopped wearing masks.  President Biden has declared May 11th the end of the COVID emergency.  However, I think that it could be naive to think that COVID is over.  We currently have around 500 deaths per day.  New mutations keep popping up and some of these might not be so bad, but there is always the potential for a new deadly strain to arise.  The XBB 1.5 variant is so infectious there is a possibility that everyone will get it, and it has killed 1,600 New Yorkers since December 1st.

I suspect that we will be fighting COVID for the rest of our lives.

Almost nobody has time to read scientific literature.  This is one reason we pay politicians to make policy so that we don't have to sort through all the details ourselves.  And most people are fine with that.  However, only 68% of the U.S. population is fully vaccinated, with around 21% having never been vaccinated.

I am personally angry with the anti-vax crowd because they seem to only think about themselves.  There are some very small risks associated with the vaccines, so many people assume that if they are young and healthy that they are better off not getting vaccinated.  These assumptions may not be correct, since many young healthy people also have died from COVID-19.  However, the reason for my consternation is that the anti-vax crowd seems to not care at all about people like my elderly mother whose health issues would make her extremely vulnerable to COVID.  If a person chooses not to be vaccinated, then they are choosing to likely spread COVID to someone else, because the R factor of the Omicron variant is 3.4.  In the past, anything with an R factor of 1 or higher was considered serious.

I like to say that the anti-vax crowd cherry-picks their data, but that is being generous.  For the most part, they don't look at data.  They see statements on social media, Youtube, and fringe conspiracy-theory websites made by very questionable people, and they believe in some of the most absurd positions as if they were gospel.  I have spent 2 years fighting vaccine misinformation on the Internet, but I give up because apparently, you can't reason with irrational people.

I see claims every day that I know have been debunked by at least one scientific study.  The most recent one is that the mRNA vaccines don't stop the spread of the disease.  There are studies that say otherwise.  

Some commentators who I would normally respect think that the government has been lying to us this whole time.  They are calling for the prosecution of government officials for their "COVID lies".

What the data currently shows is that there is much lower overall mortality for people who have been vaccinated.  There is a small health risk with the vaccines, but COVID-19 is no ordinary disease.  It attacks every organ in the body.  The health complications from COVID are far more dangerous than the vaccines.

--
Best wishes,

John Coffey

Thursday, January 26, 2023

Bill Maher goes NUCLEAR on COVID Tyranny

https://youtube.com/shorts/0MXPmTdfIkI?feature=share

I agree about mandates. I disagree about vaccine hesitancy in the midst of a deadly worldwide pandemic.

If this were smallpox, with a death rate 30 times higher, how many people would be opposed to the vaccine? But when it is your family member who dies from COVID-19, the death is no less significant.

Best wishes,

John Coffey

Tuesday, January 24, 2023

Vaccines



I tried really hard to convince one of my friends in Utah about vaccines, but he will have none of it. He told me that he doesn't believe in any vaccine. Therefore, I told him I don't want to waste any more of my time and will stop bugging him about it.

Unfortunately, he is not a lone case. I have several friends who are opposed to the COVID-19 vaccines. Only 68% of the U.S. population is fully vaccinated against COVID-19.

I could have asked him what he would do if a rabid animal bit him?  There is only one cure, and it is a vaccine. Otherwise, it is certain death.

Why is it that Polio and Smallpox are no longer a problem?

--

Monday, January 23, 2023

Vaccines Will Not Produce Worse Variants | Science | AAAS

'And past antibodies, there's the whole T-cell system - those T cells are looking to recognize human cells that have been attacked by the virus, whereupon they move in to kill them off before they can break open like a piñata and release a big pile of new viral particles. They are primed for this task by having pieces of viral proteins presented to them by other immune cells, and these T cells become specifically sensitized to the appearance of these in the future - these pieces get taken to the surface of infected cells by the MHC glycoproteins where the T cells can detect them. So you can see that in all of these cases, the key is protein surface recognition, which tells you how viruses can work their way around to evading such attacks. They have to change their surface proteins in such a way that they can still function, but that defeats that antibody/T-cell binding that the immune system has settled in on.

That's not so easy, because (for one thing) there are an enormous number of different antibodies involved (and an enormous number of T-cell recognition proteins). There are any number of ways to bind to a given protein target, and the adaptive immune system's whole function is to be ready for all kinds of targets and to hit them in all kinds of ways. And there's that constraint mentioned above: the virus still has to be able to function! Losing the entire Spike protein or mutating it completely beyond recognition would definitely evade vaccine-induced immunity, but it would also definitely produce a coronavirus that couldn't infect human cells in the way it's completely evolved to do. Coming up with a completely new infection route is (mutationally) extremely costly and complex, and not something that can be done "on the fly". Various coronaviruses use different human cell surface proteins to do their attack, but these have gradually developed and diverged over evolutionary time (hundreds of thousands, or millions of years) through untold numbers of tiny steps.

But it can be done, in principle. And as with everything in evolution, if it gets done at all, it'll get done by similarly untold numbers of individual mutants, and mutants on top of those mutants, until something appears that can both avoid being inactivated by the immune response and still infect cells and reproduce. There is no guarantee that such a virus can exist, and there is no guarantee that it can't. Evaluating the number of possibilies is frankly beyond computation - we didn't, for example, see the details of the Delta variant coming, and if you'd given someone that exact sequence last year, there's no guarantee that they would have been able to predict how much more infectious it would be.

The more chances you give the coronavirus to reproduce, the more mutations it will explore. Its proofreading system for reproduction is pretty good but not perfect, and that's where the mutations come from. It's a numbers game all the way. The virus is not thinking about how to evade vaccine-induced immunity; it's throwing stuff randomly against every available wall in every available direction, and whatever sticks gets a chance to go on throwing some more. Remember, an unvaccinated person is still mounting an antibody defense against the virus - they're just having to do it from scratch, rather than having a pre-primed leg up like someone who's been vaccinated. The longer these infections go on inside human bodies, the more bets the virus gets to put down on the table. The good news is that so far, there is not much evidence that the virus is doing much evasion inside a given person during the course of normal infection.

So one key way to cut down on the odds of a nasty mutant popping up is to just keep the virus from reproducing so much. Cut down on the number of people it infects. When it does infect people, cut down on the amount of time it spends reproducing inside the body. These countermeasures are exactly what a mass vaccination program does. Fewer people get infected in the first place, and when they do get infected, their disease course tends in the great majority of cases to be shorter and milder. A nasty variant is almost certainly going to come up by accident, so let's not have so many accidents going on constantly around the clock, around the world.
...
a true vaccine-evading mutant is going to need a set of several mutations (off the existing variants) all at the same time. The vaccine-induced immune response looks like it's knocking down a lot of these intermediate-step mutations before they can keep on throwing off subsequent mutations on top of the first ones. These pathways are choked off before they can even get explored, and this "evolutionary smothering" is something that you don't see so dramatically when you're doing those in vitro experiments with specifically targeted small molecules mentioned at the top of this post. A broad antibody and T-cell response is a different thing altogether.

There is, then, every reason at both the population and individual level to expect that vaccination will strongly decrease the chances of a more dangerous coronavirus strain taking hold. If we'd had them earlier and were able to deploy them quickly and widely enough, we never would have seen the Delta variant in the first place. If we keep deploying them now, we will keep worse variants from even being able to form. Anyone who tells you that vaccines will make things worse is at best deeply misinformed and at worst lying to you for profit.'

https://www.science.org/content/blog-post/vaccines-will-not-produce-worse-variants

Saturday, January 21, 2023

Fwd: Re: Getting vaccinated for covid four or more times results in near-complete collapse of the immune system, bombshell study finds

FYI.

---------- Forwarded message ---------
From: John Coffey <john2001plus@gmail.com>
Date: Sat, Jan 21, 2023 at 12:01 PM
Subject: Re: Getting vaccinated for covid four or more times results in near-complete collapse of the immune system, bombshell study finds
To: <beesley1>


"The study comes from China, which is where many believe the Wuhan coronavirus (Covid-19) originated. It shows that after the fourth injection – meaning the two primary jabs and two subsequent booster shots – a person's immune system is pretty much shot"

China has none of the mRNA vaccines used in the United States.  The vaccine they developed reportedly does not work very well.

I get frustrated when they don't link to the study but claim that they have seen it.  They make you dig pretty deep to find it.

https://www.sciencedirect.com/science/article/pii/S2589004222017515
https://pubmed.ncbi.nlm.nih.gov/36338436/



You are being lied to.  People are exploiting you.

https://healthfeedback.org/authors/ethan-a-huff/

https://ourworldindata.org/grapher/united-states-rates-of-covid-19-deaths-by-vaccination-status?country=~50%2B

https://healthfeedback.org/outlet/natural-news/

https://www.reuters.com/article/factcheck-coronavirus-britain/fact-check-covid-19-vaccines-do-not-weaken-peoples-immune-systems-like-chemotherapy-idUSL1N2SY1SP


I suggest that in order to be better informed, you try to look at as much scientific research as possible.  I have tried to do that.

The mRNA vaccines have side effects.  Most of these are mild.  There are rare cases of myocarditis on the order of 2 per hundred thousand vaccinations.  Most of this has been mild and easily treatable.  Another study said that there may have been 2 deaths per million people vaccinated.  When it comes to deaths on this small of a level then you have to consider that there may have been other factors.  One death was attributed to other comorbidities.

However, another study showed that the COVID-19 disease is 1,000 to 2,000 more likely to cause myocarditis, and the current death rate of the disease is around 1.1%.

COVID-19 is not a normal disease.  It attacks every organ in the body, including the brain.  One study showed an average of 2% brain shrinkage from the disease.  The normal rate of brain shrinkage is 0.1 to 0.2% per year.  COVID-19 can have serious long-term consequences for your health including your heart health.

COVID-19 is not a normal disease.  The spike protein makes it look like it was manufactured in a lab.  I think that it is possible that the Chinese made this, but I have by no means ruled out a natural origin.  Most diseases like this arise from natural sources. 

The vaccine is not completely safe, nor is it totally effective against variants.  A study published in the New England Journal of Medicine on May 12th, 2022, found that the previous booster was 49% effective at preventing infection from the Omicron variant.   I'll take that over nothing.  A more recent study showed increased effectiveness of the bivalent booster which I got in September.

Pick your poison.  If you do not get the vaccine then you will at some point get COVID-19 again.  You will probably be okay, but you also risk your health as well as the health of those around you.  The next case of COVID could be worse.

There is some chance that I also will get the new COVID strain because it is so infectious.  However, studies have shown that the vaccine reduces the likelihood of hospitalization and death.

There is nothing wrong with my immune system as far as I know.  I've been vaccinated for COVID-19 five times and I have been unusually disease free.  I normally get a respiratory virus a couple of times per year and I have not had a virus since COVID began.

Best wishes,

John Coffey


On Sat, Jan 21, 2023 at 2:59 AM Beesley wrote:
>
> Getting vaccinated for covid four or more times results in near-complete collapse of the immune system, bombshell study finds.
>
>  
>
> https://www.naturalnews.com/2023-01-20-covid-vaccination-four-injections-collapse-immune-system.html#
>
>  
>
> . . . . .
>
> "What covid jabs do, based on these findings, is damage natural immune function. They interfere with the innate-adaptive immune balance, leaving the host more prone to infection – which goes against everything we have been told by the "authorities" about these shots."
>
> "The damage caused by covid injections extends far past just antibodies, which function as the immune system's front-line defense against viruses and bacteria. T-cells, which serve as a backup to antibodies, also become damaged – seemingly without any ability to repair."
>
> "The study was published without much fanfare on Dec. 22, 2022, in the peer-reviewed journal iScience. It unequivocally shows, as Berenson is reporting, that covid boosters – and really all covid shots – are a death sentence for one's immune system."
>
> . . . . .
>
>
> Virus-free.www.avast.com


Friday, January 13, 2023

CDC identifies possible 'safety concern' for certain people receiving COVID vaccines | Fox News

"Rapid-response investigation of the signal in the VSD raised a question of whether people 65 and older who have received the Pfizer-BioNTech COVID-19 Vaccine, Bivalent were more likely to have an ischemic stroke in the 21 days following vaccination compared with days 22-44 following vaccination."

In a statement to Fox News Digital, a spokesperson for Pfizer said, "Pfizer and BioNTech have been made aware of limited reports of ischemic stroke that have been observed in the CDC Vaccine Safety DataLink (VSD) database in people 65 and older following vaccination with the Omicron BA.4/BA.5-adapted bivalent COVID-19 Vaccine by Pfizer and BioNTech."

The agency also said that the Vaccine Adverse Event Reporting System (VAERS) managed by CDC and FDA has not seen an increase in reporting of ischemic strokes following the updated (bivalent) vaccine.

"Neither Pfizer and BioNTech nor the CDC or the U.S. Food and Drug Administration (FDA) have observed similar findings across numerous other monitoring systems in the U.S. and globally and there is no evidence to conclude that ischemic stroke is associated with the use of the companies' COVID-19 vaccines," the spokesperson continued. 

"Compared to published incidence rates of ischemic stroke in this older population, the companies to date have observed a lower number of reported ischemic strokes following the vaccination with the Omicron BA.4/BA.5-adapted bivalent vaccine. The CDC continues to recommend vaccination with the Pfizer-BioNTech Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine for all authorized ages and indications."

Thursday, January 12, 2023

sleeping position prevents dementia

---------- Forwarded message ---------
From: Larry 

Sleeping on your side is generally considered the healthiest sleeping position — this is because it gives good support for your spine, while also minimizing acid reflux.  

On Thu, Jan 12, 2023 at 9:52 AM Larry wrote:

Sleeping in a certain position helps lower the risk of dementia, studies have found.

Sleep expert Narwan Amini said: "Sleeping on your side has been found to be the most beneficial position for your brain, with the position helping your brain to clear out interstitial waste faster than other positions.

"This leads to multiple benefits including potentially reducing the risk of developing neurological diseases such as Parkinson's or Alzheimer's."

The sleeping position that slashes your risk of developing dementia (nypost.com)


Wednesday, January 11, 2023

COVID vaccine related deaths

Andy Saffle
Well then someone needs to explain why the COVID Vaccinated men Are dropping like flies From Sudden Heart failure and that COVID Vaccinated men, for some odd reason have the highest Rates if Myocarditis ever seen...

Andy Saffle "Well then someone needs to explain why the COVID Vaccinated men Are dropping like flies From Sudden Heart failure".
This is a total lie.
"All the data listed in that story came from the VARES system".
With 200 million vaccinated people in the United States, a certain number of them are going to have adverse events regardless of whether they are vaccinated or not. The data showed a much lower death rate for vaccinated people, including non-COVID deaths.



John Coffey well that didn't age well did it.. I'm seeing 3 to 5 different #diedsuddenly stories daily. Mostly young athletes, men and women, died of some type of cardiac event... That MMA women prodigy who was 18 and literally just dropped dead.. her family released a photo of what the Morgue pulled out of her blood during embalming . I'm on top of this brother. I know of 200 others that have had similar clots pulled out during embalming... They only thing they have in common is the Covid Vaccine.. WHICH IS CAUSING MYOCARDITIS AND CLOTTING, and the manufacturers are admitting this.. they are also admitting this this MRNA tech.was never tested before release an authorization.. I'll gladly show some of the pictures of the clotting if you would like

Andy Saffle
John Coffey not even an hour difference and this one pops up( I know he isn't an athlete)


John Coffey here's another that popped this morning.. this guy definitely qualifies as an athlete


John Coffey
Anecdotal evidence is not scientific. People have been dying of heart attacks long before vaccines. The articles you quote don't mention the vaccine. Confirmation Bias causes people to believe Anecdotal evidence as proof because it confirms their preconceived notions.
We arrive at the truth through peer-reviewed studies that take into account how vaccines affect large groups of people.
The data shows that mRNA-vaccinated people have a lower death rate even from non-COVID illnesses. Whatever risk there may be is very low compared to the risk of COVID-19, which according to a study that I already quoted shows that the risk of myocarditis/pericarditis is 1000 to 2000 times higher with the disease than it is with the vaccine.
Although the AstraZeneca COVID-19 vaccine was associated with rare blood clots, which caused it to be banned in some areas, there is no evidence that the mRNA vaccine causes blood clots.
Glenn Beck has trafficked in a ton of conspiracy theories. I don't consider him nor The Blaze to be a reliable source of information. You are being lied to by people who want to exploit you.
The most damning study I found said that the vaccine is associated with 2 deaths per million doses. Although that sounds high, that is low enough to be random noise when you consider that people die all the time from many causes. Meanwhile, in the United States, 1.1% of cases died from the disease with 1.1 million deaths. My cousin on her deathbed expressed regret about not getting the vaccine.

You can go through life believing in BS and that is your right. I just don't think that it is in your best interest. People who believe in these false theories put themselves and others at greater risk.