Thursday, January 29, 2015
Monday, January 26, 2015
Treated cells behave as if they are much younger than untreated cells, multiplying with abandon in the laboratory dish rather than stagnating or dying.
The procedure, which involves the use of a modified type of RNA, will improve the ability of researchers to generate large numbers of cells for study or drug development, the scientists say. Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells. The research may point to new ways to treat diseases caused by shortened telomeres.
Telomeres are the protective caps on the ends of the strands of DNA called chromosomes, which house our genomes. In young humans, telomeres are about 8,000-10,000 nucleotides long. They shorten with each cell division, however, and when they reach a critical length the cell stops dividing or dies. This internal "clock" makes it difficult to keep most cells growing in a laboratory for more than a few cell doublings.
'Turning back the internal clock'
"Now we have found a way to lengthen human telomeres by as much as 1,000 nucleotides, turning back the internal clock in these cells by the equivalent of many years of human life," said Helen Blau, PhD, professor of microbiology and immunology at Stanford and director of the university's Baxter Laboratory for Stem Cell Biology.
While 94 percent of California kindergarteners were fully inoculated against the virus last school year, according to the U.S. Centers for Disease Control and Prevention, there are clusters where vaccination is much lower. In some pockets of California, as much as a quarter of children are undervaccinated -- putting them at risk of both contracting the disease and becoming a nexus of future spread.
"Children die as a result of this disease," said Greg Poland, professor of medicine and infectious diseases at the Mayo Clinic in Rochester, Minnesota, and director of the Mayo Vaccine Research Group. "In 1990, 3 of every 1,000 children who got measles died from it. That wasn't the dark ages. We don't have an effective treatment for measles. The only thing we have is prevention."
Friday, January 23, 2015
Now researchers at UCLA have treated ASD mice with a neuropeptide--molecules used by neurons to communicate with each other--called oxytocin, and have found that it restores normal social behavior. In addition, the findings suggest that giving oxytocin as early as possible in the animal's life leads to more lasting effects in adults and adolescents. This suggests there may be critical times for treatment that are better than others.
The study appears in the January 21 online edition of the journal Science Translational Medicine.'
Saturday, January 17, 2015
Friday, January 9, 2015
For 21 days, a team of scientists at Wake Forest Baptist Medical Center monitored the effects of manufactured insulin on 60 adults with either mild cognitive impairment (MCI) or moderate Alzheimer's dementia (AD). One group was given 40 units of the nasal insulin detemir, another was given 20 units and a third group was given a placebo.
Of the three groups, short-term ability to process verbal and visual cues increased the most in those who were given 40 units of the spray. That same dosage of the spray was also able to increase memory scores for those carrying the gene that increases a person's risk for dementia the most. Carrying that particular gene usually makes the body resistant to most treatments.'
I already forgot what the article is about.
Thursday, January 8, 2015
This week, some of them took the first step to stealing the bowhead whale's secrets: They sequenced its genome. Their results were published Tuesday in Cell.
"I think that having the genome sequence of the bowhead whale will allow researchers to study basic molecular processes and identify maintenance mechanisms that help preserve life, avoid entropy and repair molecular damage," said corresponding author Joao Pedro de Magalhaes of the University of Liverpool.'
The last new class of antibiotics to make it to clinic was discovered nearly three decades ago.
The study, in the journal Nature, has been described as a "game-changer" and experts believe the antibiotic haul is just the "tip of the iceberg".
The heyday of antibiotic discovery was in the 1950s and 1960s, but nothing found since 1987 has made it into doctor's hands.
Since then microbes have become incredibly resistant. Extensively drug-resistant tuberculosis ignores nearly everything medicine can throw at it.
Back to soil
The researchers, at the Northeastern University in Boston, Massachusetts, turned to the source of nearly all antibiotics - soil.
This is teeming with microbes, but only 1% can be grown in the laboratory.
The team created a "subterranean hotel" for bacteria. One bacterium was placed in each "room" and the whole device was buried in soil.
It allowed the unique chemistry of soil to permeate the room, but kept the bacteria in place for study.
So California cannot ban something Federal law allows….Colorado can allow something Federal law bans….and Arizona cannot pass a law identical to federal law to ban the same thing federal law does.