Saturday, October 1, 2022
At-Home COVID-19 Antigen Tests-Take Steps to Reduce Your Risk of False Negative: FDA Safety Communication | FDA
Friday, September 16, 2022
Thursday, September 8, 2022
Sunday, September 4, 2022
Wednesday, August 31, 2022
Monday, August 29, 2022
Friday, August 26, 2022
Sunday, August 21, 2022
Sunday, August 14, 2022
Saturday, August 13, 2022
From: John Coffey
On Monday someone attended the Greenwood Chess Club who was symptomatic and later tested positive for COVID-19. If you attended the chess club on Monday, I suggest taking an in-home test. I tested myself and the test came out negative. However, I quarantined this week just in case.
You can get free tests from the government. They take several weeks to get delivered. https://www.covid.gov/tests
Drug stores also sell COVID-19 tests.
I feel like I should not have to say this again, but please do not come to the Greenwood Chess Club if you are feeling sick or if you have symptoms.
There is much misinformation being spread about COVID, so I will address some of these issues here:
1. The pandemic is over.
It used to be that measles was the most infectious disease on record, but the Omicron variant has surpassed measles. In early November of last year, we had barely heard of the Omicron variant, but by late January of this year, it had caused a major surge in the United States.
2. Cloth masks don't work.
People who attack mask usage always say that cloth masks don't work, which is true. However, they ignore that other types of masks are at least partially effective at preventing the spread of COVID.
"Wearing an N95/KN95 respirator (aOR = 0.17; 95% CI = 0.05–0.64) or wearing a surgical mask (aOR = 0.34; 95% CI = 0.13–0.90) was associated with lower adjusted odds of a positive test result compared with not wearing a mask (Table 3). Wearing a cloth mask (aOR = 0.44; 95% CI = 0.17–1.17) was associated with lower adjusted odds of a positive test compared with never wearing a face covering but was not statistically significant."
3. Vaccines don't prevent the spread of COVID.
As the virus has evolved, it reportedly has been more likely to have a vaccine breakthrough infection.
"Raw data shows the risk of breakthrough cases is very small for vaccinated people, potentially 1 in 5,000.
Additionally, the risk of being hospitalized from COVID-19 after vaccination is extremely small, at about 5 in 100,000.
A new study found people who were not vaccinated were five times as likely to get COVID-19 compared to people who were fully vaccinated."
"COVID 19 vaccines are effective at protecting people from getting seriously ill, being hospitalized, and even dying."
"Booster Shots of COVID-19 Vaccines Effective Against Omicron Subvariant"
Friday, July 29, 2022
Wednesday, July 27, 2022
Tuesday, July 26, 2022
Thursday, July 14, 2022
Tuesday, July 12, 2022
Saturday, July 9, 2022
— Miss Piggy
Thursday, July 7, 2022
The subvariant of Omicron known as BA.5 is now dominant, according to federal estimates released Tuesday, and together with BA.4, another subvariant, it is fueling an outbreak of cases and hospitalizations.
"I think there's an underappreciation of what it's going to do to the country, and it already is exerting its effect," said Eric Topol, a professor of molecular medicine at Scripps Research, who has written about the subvariant.
BA.5 and BA.4, both subvariants of the Omicron variant that swept the world during the winter, are the most capable versions of the virus yet at evading immunity from previous infections and vaccines. Both variants have mutations in their spike proteins that are different enough from earlier versions of the virus that they are able to dodge some antibodies.
Waves of infection — and the subsequent immunity that comes with them — vary across countries and make for imperfect comparisons. Vaccination rates also vary. But in places where BA.4 and BA.5 have been dominant for weeks or months, the subvariants have caused increases in cases and hospitalizations, despite some population immunity from previous waves
Sunday, July 3, 2022
Tuesday, June 28, 2022
Saturday, June 25, 2022
Saturday, June 18, 2022
Dunn said hospitals in Utah have been "stable" until this week. The state dashboard reports a 27.3% increase in the seven-day average of COVID-19 hospitalizations, and a 35.3% jump in seven-day average cases in the ICU.
"The silver lining in this increase is that it's definitely not as steep," she said. "It's happening at a slower pace."
Dunn said the increase in cases could be from new Omicron subvariants and vaccination/booster shot immunity wearing off.
"We're starting to see that increase and with that, an increase in positivity," said Dunn. "So we're now seeing 25% to 30% positivity."
She said current positivity rates mirror similar peaks seen in early 2021 and beyond.
"The people-over-people method is up 625% since April 2," she explained. "The testing-over-testing method is up 850%."
Tuesday, June 7, 2022
Friday, June 3, 2022
Wednesday, June 1, 2022
The breakthrough stems from the team's explorations in what's known as intracellular thermogenesis, an emerging field that centers on gauging temperature changes within cells. Advanced sensors have made such measurements possible, and the team is the first to apply it to the study of Alzheimer's disease, focusing their attention on one of the prime suspects in its onset known as amyloid-beta proteins.
The buildup of amyloid-beta proteins into toxic clumps is considered a key driver of the neurodegeneration associated with Alzheimer's disease, and they therefore receive considerable attention from scientists working to better understand the condition. The Cambridge team had been investigating links between intracellular thermogenesis and amyloid-beta aggregation, and these advanced new sensors provided the perfect tools to delve into the details.
"Thermogenesis has been associated with cellular stress, which may promote further aggregation," said Chyi Wei Chung, the study's first author. "We believe that when there's an imbalance in cells, like when the amyloid-beta concentration is slightly too high and it starts to accumulate, cellular temperatures increase."
Tuesday, May 31, 2022
But bai lan has a more worrying layer in the way it is being used by young people in China: to actively embrace a deteriorating situation, rather than trying to turn it around. It is close to other Chinese phrases, for example 'to smash a cracked pot' (破罐破摔) and 'dead pigs are not afraid of boiling water' (死猪不怕开水烫).
State media have taken note of this trend. "Why modern young Chinese like to 'bai lan'?" one recent article in official media outlet asked. "In fact, this is as a result of negative auto suggestion, repeatedly telling oneself I cannot make it… And this kind of mentality often leads people to adopt the 'bai lan' attitude."
But the reality is not quite as state media suggested, says Sal Hang, a 29-year-old creative industry professional in Beijing. He says that for his generation of young Chinese, this attitude of letting things rot is likely to be caused by a lack of social mobility and increased uncertainty in today's China.
"Unlike my parents' generation, young Chinese today have much bigger expectations, but there are many more uncertainties for us, too. For example, we cannot make any long-term plans for our lives anymore, because we do not know what is going to happen to us even five years down the road."
Monday, May 30, 2022
The upshot? I'm sure Tony is a great personal transformation speaker and obviously, he has a passion for whatever he does. However, at this point, my concern is that my patients are seeing his interviews on social media, and in my opinion, they are getting wildly misinformed."
Saturday, May 28, 2022
Friday, May 27, 2022
The lies about Covid vaccine keep co I got. I think there is no end to it.
From: John Coffey <email@example.com>
Monday, May 16, 2022
"SARS-CoV-2 Spike Proteins Disrupt the Blood-Brain Barrier, Potentially Raising Risk of Neurological Damage in COVID-19 Patients"
"A lot of people think of it as a respiratory disease, but it's really a vascular disease," says Assistant Research Professor Uri Manor, who is co-senior author of the study. "That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings."
"If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,"
COVID-19 spike proteins may cause neurological issues
There is some previous evidence to suggest that following Covid-19 illness, the spike protein can remain in the bloodstream after the virus has gone and travel far from the site of infection. This research could help explain and ultimately treat some of the effects of severe Covid-19 infection, where levels of the virus are particularly high. "
Interestingly, it has been shown that HSV-1 spike protein binds to heparin and increases the aggregation of amyloid β (Aβ42) peptides on its surface spikes . This study suggests that the heparin-binding site of the spike protein might act as a binding site for Aβ42 peptides and thus could dock to the viral surface and catalyze aggregation of Aβ42. As the receptor binding domain (RBD) of SARS-CoV-2, which is located within the S1 subunit of spike glycoprotein has several heparin binding sites [, , ], the same mechanism of aggregation of neurodegeneration causing proteins such as Aβ, α-synuclein, tau, prions, and TDP-43 can be observed in COVID-19 infection in the brain."
The vaccine spike protein is different.
US fact checking website Health Feedback, which uses experts to verify claims about health science, said Dr Bridle's statement "rests on the assumption that if the viral spike protein causes cardiovascular toxicity in COVID-19 patients, the spike protein produced in vaccinated people should be toxic as well".
However, Health Feedback said this assumption was incorrect: "While both mRNA vaccines and viral vector vaccines carry the instructions to produce the entire spike protein, the cells break down much of the protein into small fragments. Furthermore, unlike infection, the spike protein from COVID-19 vaccination doesn't get assembled into new viral particles."
"Vaccine skeptics have seized on the study to cast doubt on the safety of vaccines. But a review of the study's findings shows that the concerns raised by vaccine doubters are much ado about nothing.
The vascular endothelium is an important player in the illness and death associated with COVID-19. The endothelium is a system of cells that line and protect the inside of blood vessels. SARS-CoV2 injures the endothelium leading to blood clots, heart attack, pulmonary embolism, and stroke. Despite the established link between COVID-19 and these cardiovascular complications, the mechanism by which they develop is unknown.
Researchers from Jiaotong University; the University of California, San Diego; and the Salk Institute used a pseudovirus coated with spike protein to investigate the effects of the viral protein on endothelial cells. Pseudoviruses – which were first developed over 50 years ago – contain the outer shell of the virus, but they lack the viral genes needed to reproduce.
Hamsters treated with the spike protein coated pseudovirus showed lung damage similar to that seen in humans infected with SARS-CoV2. When researchers added pseudovirus to cultured endothelial cells they found that the mitochondria inside the cells were injured. Since mitochondria are responsible for providing energy to cells, their dysfunction can cause cell death.
When isolated pulmonary arteries were exposed to the spike protein carrying pseudovirus there was some disruption in the ability of the blood vessels to dilate. The decreased ability to expand blood vessels that serve the lungs could impair the ability of the body to take up oxygen from lungs that are damaged by the virus.
The novelty of this study was the discovery that the spike protein itself causes damage, and that the pathway triggered by the spike protein could explain the widespread cardiovascular complications that develop in COVID-19 patients.
A Twisted Tale
Shortly after Lei and colleagues published their study, vaccine skeptics touted the findings as proof that newly developed COVID-19 vaccines are dangerous. Afterall, if COVID-19 vaccines produce spike protein to trigger immunity, and that same spike protein causes injury, then vaccines are really no different than the disease they are designed to prevent.
The problem with these claims is that science doesn't support their arguments.
The Long Road to Perdition....
In order to damage the endothelium of blood vessels, COVID-19 vaccines have to enter the vascular system and infect cells that circulate in the blood. Data collected by the European Medicines Agency shows that no significant amount of vaccine enters the circulation (3). The confinement of the expressed spike protein away from the circulatory system significant prevents it from causing damage to the vascular endothelium.
Redesigning the Spike Protein
The spike protein attaches SARS-CoV2 to cells through a receptor called ACE2. In order to fully interact, the spike protein must undergo a conformational change.
A research team lead by Dr. Barney Graham from the Vaccine Research Center at the NIH National Institute of Allergy and Infectious Diseases created an engineered form of the spike protein that is unable to make the shape change required to effectively bind to cells (5). The Pfizer/BioNTech, Moderna, Novavax, and Johnson & Johnson vaccines all use this inactivated spike protein, which means any spike protein that is produced by the vaccine is not able to be activated. This safety-switch limits the ability of the spike protein to bind ACE2 and limits its ability to cause damage.
Stuck in a Hole
In addition to engineering the spike protein so it can not be fully activated the protein is tagged with an extra piece called a "transmembrane anchor" (6). The transmembrane anchor allows the spike protein to appear on the surface – or membrane – of the cell, but it is held in place by the anchor. This prevents the spike protein from drifting away and creates a fixed target for the immune system to recognize the foreign protein."
So far, there is no scientific evidence available that suggests that spike proteins created in our bodies from the COVID-19 vaccines are toxic or damaging our organs. COVID-19 vaccines are relatively new and long-term side effects are yet to be known. However, the vaccines have met the safety standards of many government and international safety agencies.
Several systems help us monitor vaccine safety. In the United States these include the Vaccine Adverse Event Reporting System (VAERS), The Vaccine Safety Datalink (VSD), the Post-License Rapid Immunization Safety Monitoring (PRISM), and the Clinical Immunization Safety Assessment Project (CISA). These systems are used by scientists to monitor side effects and any other patterns of risks from vaccines.
The COVID-19 vaccine has been administered to 135 million people in the United States. As expected with any vaccine, some fully vaccinated people still got sick, hospitalized, and/or died. These "breakthrough cases" are a very small percentage of those vaccinated (<0.001%) and are being studied to detect any relevant patterns.
So far no scientific evidence is available that gives credence to claims that spike proteins created from vaccines travel in our bloodstreams. Research shows that spike proteins stay stuck to the surface of the cells around the vaccine's injection site. They are not known to wander around to other parts of the body.
A very tiny dose of the vaccine does make it to the bloodstream (about 1%), but as soon as it gets to the liver, the enzymes there destroy it completely. The U.S. CDC refers to the spike protein made from the vaccine as "harmless."
There is no evidence that the spike protein in vaccines "is toxic or that it lingers at any toxic level in the body after vaccination," an FDA spokesperson told us in an email.
Jason McLellan, a structural biologist at the University of Texas at Austin who has been studying spike proteins in other coronaviruses for years and whose work was fundamental for the development of COVID-19 vaccines, said Bridle's statements are not correct.
"The spike protein is not pathogenic. It is not a toxin," McLellan told us in an email. "I have not seen any data to support what Bridle claims."
How long does the mRNA vaccine stay in the body?
However, a separate study recently published in the New England Journal of Medicine shows that heart inflammation events are far more likely after COVID-19 infection than vaccination."
"But because reinfection is possible and COVID-19 can cause severe medical complications, it's recommended that people who have already had COVID-19 get a COVID-19 vaccine. A recent study showed that unvaccinated people who already had COVID-19 are more than twice as likely as fully vaccinated people to be reinfected with COVID-19.
Recent research also suggests that people who got COVID-19 in 2020 and then received mRNA vaccines produce very high levels of antibodies that are likely effective against current and, possibly, future variants. Some scientists call this hybrid immunity."
Sunday, May 1, 2022
Saturday, April 30, 2022
Wednesday, April 27, 2022
Saturday, April 23, 2022
Cognitive tests identified differences between COVID-19 survivors and controls, including a significant increase in the time taken to complete Trails A (numeric; 7.8%) and B (alphanumeric; 12.2%) of the Trail Making Test in COVID-19 participants. These results held true when excluding the 15 hospitalized patients (Trail A, 6.5%; Trail B, 12.5%).
"The infected participants also showed on average larger cognitive decline between the two timepoints," the study authors wrote. "Importantly, these imaging and cognitive longitudinal effects were still seen after excluding the 15 cases who had been hospitalised."
Not all COVID survivors have brain changes
In addition to the modest COVID-19 effect, the study authors noted that the statistics represent an average effect, meaning that not every COVID-19 survivor will experience brain changes.
Thursday, April 21, 2022
Tuesday, April 19, 2022
What advice would I pass on to young people seeking transition? Learning to fit in your body is a common struggle. Fad diets, body-shaping clothing and cosmetic surgery are all signs that countless millions of people at some point have a hard time accepting their own reflection. The prospect of sex can be intimidating. But sex is essential in healthy relationships. Give it a chance before permanently altering your body.
Most of all, slow down. You may yet decide to make the change. But if you explore the world by inhabiting your body as it is, perhaps you'll find that you love it more than you thought possible.
Thursday, April 14, 2022
Wednesday, April 6, 2022
Tuesday, March 29, 2022
You can get your 4th shot now.Second COVID-19 booster shot authorized for Americans 50 and older - NBC News
Monday, March 28, 2022
Shanghai a city of 26 million shuts down tunnels, bridges and highways in a covid lockdown to begin mass testing.Oil dropped almost 3% in response.
Friday, March 25, 2022
Sunday, March 20, 2022
Saturday, March 19, 2022
Friday, March 18, 2022
Date: Fri, Mar 18, 2022 at 1:31 PM