The actual science of the "industrial seed oil" panic

In response to an anti-seed-oil message.  Canola Oil is frequently attacked despite numerous studies that have proven the contrary.  

I also quote a study claiming that long-term Canola Oil usage may negatively impact memory.

---------- Forwarded message ---------
From: John Coffey <john2001plus@gmail.com>
Date: Fri, Oct 11, 2024 at 12:04 PM
Subject: The actual science of the "industrial seed oil" panic

https://www.youtube.com/watch?v=efTBLsv4yYs

I rarely use canola oil, but I use olive oil instead.

Conclusion

After 15 years of continuing research on canola oil since the latest review by Dupont et al.,2 evidence shows a number of potential health benefits of canola oil consumption (Figure 2). Canola oil can now be regarded as one of the healthiest edible vegetable oils in terms of its biological functions and its ability to aid in reducing disease-related risk factors and improving health. Current research is expected to provide more complete evidence to support the health-promoting effects of canola oil when consumed at levels consistent with dietary guidelines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746113/

Conclusion

CO significantly improved different cardiometabolic risk factors compared to other edible oils. Further well-designed clinical trials are warranted to confirm the dose–response associations.
https://www.nmcd-journal.com/article/S0939-4753(20)30234-9/abstract

https://www.hsph.harvard.edu/news/hsph-in-the-news/scientists-debunk-seed-oil-health-risks/

In conclusion, these studies support the safety of LBFLFK RBD oil as a source of EPA and DHA for human consumption.
https://www.sciencedirect.com/science/article/pii/S0278691518308445

Conclusion
Compared to other edible oils, CO significantly improves TC, LDL-C, Apo B, TC/HDL, LDL/HDL, and Apo B/ Apo A-1. Replacing daily consumed oils with CO at ~15% of total energy intake led to the greatest reduction in TG, TC, LDL-C, Apo B, LDL/HDL, TC/HDL, and HDL-3. Further well-designed RCTs with rigorous methodology examining dose–response and clinical outcome markers as well as mechanisms are warranted.
https://www.sciencedirect.com/science/article/abs/pii/S0939475320302349

https://www.researchgate.net/publication/237015711_Evidence_of_health_benefits_of_canola_oil

https://www.canolacouncil.org/research/oil/#canola-oil-research-directory

Discussion
The data presented in the current paper demonstrate that chronic administration of a diet enriched with canola oil results in significant deficits of working memory and synaptic pathology, but has no effect on the Aβ deposits and tau phosphorylationn levels in a transgenic Alzheimer's mouse model that develops Aβ deposits and tau neurofibrillary tangles.

Supporting the detrimental effect of chronic exposure to canola oil-rich diet on the behavior responses, we found that the same mice had biochemical evidence for a reduction in synaptic integrity as demonstrated by the significantly lower levels of PSD95 protein, a well-established synaptic marker, in the brains of the canola oil-treated mice31.

https://www.nature.com/articles/s41598-017-17373-3

On the other hand, a recent research review suggests that cooking with canola oil instead of butter or margarine can reduce the risk of dying from cardiovascular disease or diabetes. A different review found that consuming canola oil may lower total cholesterol and "bad" LDL cholesterol, especially for older adults (30Trusted Source, 39Trusted Source).More research is needed on canola oil and heart healt

SUMMARY
Some studies suggest that canola oil may increase inflammation and negatively impact memory and heart health. However, other research reports positive effects on health including the possibility that it might lower LDL cholesterol.
https://www.healthline.com/nutrition/is-canola-oil-healthy#health-impact